It attracted public attention as the residence of Queen Natalie of Serbia, whose son Alexander was returned to his native country by force in 1888 during the legendary "Serbian Prince Kidnapping".

The villa served as a setting for the filming of Thomas Mann's "Buddenbrooks". Since 1960, it has been the scene of cultural events in Wiesbaden.
The restauration of the Villa Clementine took place in 2009.