The Museum Wiesbaden is one of three state museums in the State of Hesse. Lovers of art and nature as well as art fanciers with a passion for the expressionism cannot do without visiting the museum. It owns more than 100 works of the Russian painter Alexej von Jawlensky, which forms the most important Jawlensky collection in Europe. Additionally, installations, objects, sculptures and paintings from the latter half of the 20th century form the focal points of the art collection. Moreover, this museum regularly organises noteworthy special exhibitions of international contemporary art, such as for the Ritschl prizewinner Katharina Grosse from July 10th to October 11th, 2015 or Schmidt-Rottluff's "Picture and self-portrait" exhibition in winter 2015/16.

With the reopening of the south wing in May 2013 a new presentation of the art of the 12th to the 19th century was opened to the public in the Museum Wiesbaden. Parallel to that, the "Naturhistorische Sammlungen" (Natural History Collections) opened with the new "Ästhetik der Natur" (Aesthetics of Nature) permanent exhibition in the north wing. The natural science collection comprises not only geological and mineral exhibits, but also exhibits of vertebrates and botanical exhibits. After completion of the overall refurbishments, the building now offers a tour of a broad panorama of art to nature on a 7,000 square metre exhibition area.